Anti-NAFLD Effect of SCFAs-rich Fermented Lemon by- product in Mice fed a High-Fat Diet

Ho-Shin Huang^1, , Chi-Yu Yang², Pei-Chun Lin², Chun-Mei Lu¹ and Ting-Yuan Hsu^{1, 3}

¹R&D Center, Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan

²Agricultural Technology Research Institute, No.52, Kedong 2nd Rd., Zhunan Township, Miaoli County, Taiwan

³Kao-Ho Hospital, No. 460, Bo'ai 1st Rd., Gushan Dist, Kaohsiung City, Taiwan

Cite this paper:
Ho-Shin Huang, Chi-Yu Yang, Pei-Chun Lin, Chun-Mei Lu and Ting-Yuan Hsu. Anti-NAFLD Effect of SCFAs-rich Fermented Lemon by- product in Mice fed a High-Fat Diet. Journal of Food and Nutrition Research. 2026; 14(2):45-53. doi: 10.12691/jfnr-14-2-1

Abstract

This study investigated the therapeutic potential of fermented lemon peel (FLP07) in mitigating HFD-induced NAFLD, utilizing a mouse model to compare its efficacy against the hepatoprotective agent silymarin. While HFD-fed mice exhibited significant weight gain, dyslipidemia, and intervention with FLP07 effectively improved serum triglyceride (TG) and total cholesterol (TC) levels. Furthermore, FLP07 partially restored the AST/ALT ratio and significantly reduced hepatic lipid droplet accumulation, showing comparable efficacy to silymarin. These results suggest that FLP07 is a promising natural dietary supplement for managing NAFLD and dyslipidemia.

Keywords:
Gut Microbiota High-Fat Diet (HFD) Non-alcoholic Fatty Liver Disease (NAFLD) Short-Chain Fatty Acids (SCFAs)

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