http://www.sciepub.com/journal/AJPS American Journal of Pharmacological Sciences is a peer-reviewed, open access journal that publishes original research articles and review articles on all aspects of the pharmaceutical sciences with strong emphasis on originality and scientific quality. Science and Education Publishing en 2013 Science and Education Publishing Co. Ltd All rights reserved. American Journal of Pharmacological Sciences 14 1 January 2026 2013 Science and Education Publishing Co. Ltd All rights reserved. http://pubs.sciepub.com/ajps/14/1/1 Background: Self-medication, as defined by the WHO, involves individuals treating their own health issues and has emerged as a significant public health concern worldwide, addressing billions of health issues each year. Aim: The current study was conducted to evaluate the effect of an educational program on pregnant women’s knowledge regarding possible side effects of drugs used during pregnancy on the fetus and mother. Subjects and Methods: Design: A quasi-experimental design was used. Sample and Settings: A convenient sample of 358 pregnant women was used at outpatient clinics at Beba Hospital, affiliated with the Ministry of Health, Beni-Suef Governorate. Tools: Tool 1: Women's knowledge regarding possible side effects of teratogenic drugs used during pregnancy on the fetus questionnaire sheet. Tool 2: Women's knowledge regarding possible side effects of teratogenic drugs used during pregnancy on the mother questionnaire sheet. Results: It reveals that 72.8% & 51.8% of the studied sample delayed marriage or childbearing to complete their studies or work. After program implementation, knowledge improved from 8.62±3.78 to 9.21±2.24. Females’ attitude toward oocyte preservation after program implementation improved to 48.52±4.66 compared to 36.83±4.87 preprogram. Working females’ intention regarding oocyte preservation after program implementation is 21.89±2.15 as compared to 19.74±2.98 preprogram. Using the chi-square test revealed highly significant statistical differences between females’ overall knowledge, attitude, and intentions pre- and post-program implementation (P=0.000). Conclusion: Based on the findings of the present study, it can be concluded that after program implementation, the studied female workers at Beni-Suef University had marked improvement in knowledge, attitude, and intention regarding oocyte cryopreservation compared to before program implementation. Recommendations: Advocacy campaigns on safe pregnancy medication use should utilize interactive workshops, posters, and digital resources, emphasizing educational backgrounds and teratogenic medication safety for prenatal care and community health initiatives.]]> Hagar Kamal Masoud, Heba Ahmed Mohamed, Hanan Elzeblawy Hassan 2026-01-19 Science and Education Publishing 2026-01-19 1 14 1 6 10.12691/ajps-14-1-1 http://pubs.sciepub.com/ajps/14/1/2 Candida albicans exo-β-(1,3)-glucanase (antifungal target) and Escherichia coli penicillin-binding protein 1B transglycosylase (antibacterial target). All uncomplexed peptides exhibited superior binding affinities relative to the native glucanase inhibitor (NFG, −5.4 kcal/mol), with values ranging from −6.0 to −7.7 kcal/mol against glucanase and −5.5 to −7.0 kcal/mol against PBP1B. Cu²⁺ complexation produced diametrically opposed effects on the two targets: dramatic enhancement of glucanase binding (with affinities reaching −14.81 kcal/mol for FLK11–Cu²⁺ derived from pawpaw defensin) versus near-universal loss of binding to PBP1B. Interaction fingerprint analysis revealed that Cu²⁺ complexation promotes an “interaction saturation” state within the glucanase catalytic pocket, increasing hydrogen bonding (from 3–4 to 5–6) and electrostatic contacts (from 1–2 to 3–4), consistent with metal-induced preorganization of peptide surface chemistry. In contrast, the rigid, quasi-spherical Cu²⁺–peptide assemblies were sterically incompatible with the narrow hydrophobic groove of PBP1B, leading to impaired active-site penetration despite preserved surface charge. Lead candidates identified for experimental validation include FLK11–Cu²⁺ (pawpaw defensin) and FLK12–Cu²⁺ (tomato defensin) for antifungal development, and uncomplexed FLK1 (avocado), FLK5 (pawpaw), FLK11 (pawpaw), FLK13 (tomato), and FLK14 (tomato) for antibacterial applications. Collectively, these findings establish a structure–activity framework for the rational design of pathogen-selective metallopeptide inhibitors derived from locally available plant sources and demonstrate that metal coordination can function as a switchable modality to tune target selectivity rather than a universally beneficial modification.]]> Olatomide A. Fadare, Temitayo O. Aiyelabola, Imisioluwa A. Akintola, Janet I. Michael, Rachael Y. Fadare, Chiamaka V. Chukwu, Folakemi O. Yakubu, Deborah A. Sanni, Roheemah O. Lawal, Akitsu Takashiro, Adenike Kuku 2026-05-05 Science and Education Publishing 2026-05-05 1 14 7 19 10.12691/ajps-14-1-2